Table 3 Vital sign results (safety set)

		DA-5521 (N = 23***) Mean±SD	Placebo (N = 24) Mean±SD	p-value
Pulse (beats/min)	Baseline	63.00±9.49	63.42±8.15	0.8723*
	2 h after drinking	70.04±9.71	74.17±9.92	0.1221&
	Change from baseline	7.04±10.84	10.75±9.13
	p-value**	0.0050	<.0001
	10 h after drinking	69.39±6.88	71.38±6.51	0.4718*
	Change from baseline	6.39±7.51	7.96±7.30
	p-value**	0.0005	<.0001
Systolic blood pressure (mmHg)	Baseline	117.74±7.89	115.54±7.70	0.3392*
	2 h after drinking	109.22±10.97	111.96±8.53	0.0405*
	Change from baseline	-8.52±8.17	-3.58±7.88
	p-value**	<.0001	0.0359
	10 h after drinking	116.74±8.87	115.83±8.71	0.3997&
	Change from baseline	-1.00±8.39	0.29±7.75
	p-value**	0.5733	0.8553
Diastolic blood pressure (mmHg)	Baseline	71.35±5.74	69.21±8.61	0.3236*
	2 h after drinking	60.57±8.40	64.63±9.46	0.0108*
	Change from baseline	-10.78±6.58	-4.58±9.12
	p-value**	<.0001	0.0218
	10 h after drinking	66.83±7.12	65.79±8.35	0.6765*
	Change from baseline	-4.52±6.58	-3.42±10.98
	p-value**	0.0033	0.1410
Body weight (kg)	Baseline	75.73±7.67	75.78±8.02	0.9846*
	10 h after drinking	75.44±7.63	75.50±7.85	0.8561&
	Change from baseline	-0.29±0.37	-0.28±0.59
	p-value**	0.0010	0.0307

Comparison between groups: p-value for the two-sample t-test
Comparison between groups: p-value for Wilcoxon rank-sum test
Comparison between groups: p-value for Paired t-test
Excluding one participant who dropped out after visit two (visit two: placebo, visit three: DA-5521)