Table 2 Laboratory test results (safety set)

Variables	DA-5521 (N = 23**) Mean±SD	Placebo (N = 24) Mean±SD	p-value
WBC (103/mL)	5.66±0.97	6.24±1.11	0.0621*
RBC (1003/mL)	4.81±0.22	4.86±0.23	0.4588*
Hemoglobin (g/dL)	14.98±0.66	15.10±0.75	0.5720*
Hematocrit (%)	44.16±1.97	44.55±2.09	0.5107*
MCV (fL)	91.88±3.41	91.74±2.85	0.8815&
Platelet (103/mL)	248.61±51.98	253.46±47.77	0.7405*
Neutrophil (%)	50.73±7.45	51.23±9.21	0.4758&
Lymphocyte (%)	36.77±6.63	34.46±9.22	0.6245&
Monocyte (%)	8.34±1.77	8.26±1.74	0.8820*
Eosinophil (%)	3.44±2.77	3.33±2.96	0.7737&
Basophil (%)	0.72±0.39	0.73±0.35	0.8894&
ALP (IU/L)	72.43±24.39	73.04±23.43	0.9311*
γ-GTP (IU/L)	28.17±17.17	28.83±16.10	0.7981&
AST (GOT) (IU/L)	22.30±6.57	23.46±7.68	0.7169&
ALT (GPT) (IU/L)	25.57±13.13	28.21±14.28	0.6316&
Total bilirubin (mg/dL)	0.81±0.29	0.77±0.21	0.7016&
Protein (g/DL)	6.83±0.30	4.55±0.19	0.4700*
Albumin (d/DL)	4.54±0.18	16.13±2.44	0.4510*
BUN (mg/dL)	16.3±3.71	0.90±0.08	0.8301&
Creatinine (mg/dL)	0.89±0.08	6.31±0.83	0.7977*
Uric acid (mg/dL)	6.25±0.87	9.70±0.28	0.7945*
Glucose (mg/dL)	85.09±6.81	84.63±6.52	0.2614*

Excluding 1 subject who dropped out after visit two (visit two: placebo, visit three: DA-5521)
Comparison between groups: p-value for the two-sample t-test
Comparison between groups: p-value for Wilcoxon rank-sum test
WBC, white blood cell; RBC, red blood cell; MCV, mean corpuscular volume; ALP, alkaline phosphatase; γ-GTP, gamma-glutamic transpeptidase; AST (GOT), aspartate aminotransferase; ALT (GPT), alanine aminotransferase; BUN, blood urea nitrogen