오미자 열수추출물의 대장암세포 증식억제 효과

유민주¹, 정하숙¹^,^*

Effects on Hot Water Extract of Schizandra chinensis on Colon Cancer Cell Line

Min-ju Ryu¹, Ha-Sook Chung¹^,^*

¹덕성여자대학교 식품영양학과

¹Department of Food and Nutrition, Duksung Women's University

^*Corresponding author: Ha-Sook Chung, Department of Food and Nutrition, College of Natural Sciences, Duksung Women's University, 419 Ssangmun-dong, Dobong-gu, Seoul 132-714, Korea, Tel: +82-2-901-8593; Fax: +82-2-901-8372, E-mail: hasook@duksung.ac.kr

ⓒ Copyright 2011 Korean Society for Food Engineering. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Jan 31, 2011; Revised: Jan 17, 2011; Accepted: Feb 21, 2011

Published Online: Feb 28, 2011

Abatract

The anticancer activity of Schizandra chinensis Baillon was investigated for the development of functional food resources. The antiproliferative activity of hot water extracts of Schizandra chinensis Baillon in human colon cancer cell line (HT-29) were identified using cell viability, morphology study, cell cycle and RT-PCR analyses. HT-29 cells were cultured in several concentrations (0, 1.0, 2.0, 4.0 mg/mL) of water extracts of Schizandra chinensis Baillon. In our study, colon cancer cell growth could be inhibited by hot water extracts of Schizandra chinensis Baillon in a dose-dependent manners. It was associated with morphological changes and apoptotic cell death with cell shrinking, chromatin condensation, apoptotic bodies and cell cycle analysis. These results suggest that Schizandra chinensis Baillon may inhibit the growth of human colon cancer cells by various apoptosis-aiding activities as well as apoptosis itself.

Keywords: Schizandra chinensis Baillon; hot water extraction; freeze drying; colon cancer; apoptosis